Heterozygosity and functional allelic variation in the Candida albicans efflux pump genes CDR1 and CDR2
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چکیده
منابع مشابه
Using PCR to Compare the Expression of CDR1, CDR2, and MDR1 in Candida Albicans Isolates Resistant and Susceptible to Fluconazole
Abstract Background and objectives: More Candida albicans strains are reported resistant to fluconazole in patients with AIDS, cancer and organ recipients. Fluconazole resistance can be attributed to changes in pathways of sterol biosynthesis, mutation in or overexpression of ERG11 and the expression of CDR1, CDR2, and MDR1. This study aimed to compare the ex...
متن کاملTranscriptional Regulation of CDR1, a major efflux pump involved in multidrug resistance in Candida albicans
Candida albicans apart from being the most common human fungal pathogen is also the omnipresent component of the mammalian micro biome. In recent years, the incidence of fungal infection has shown a remarkable increase. Candida albicans, is one of the major fungus which is found to be responsible for skin infections (Morrison et al, 2006). Candida albicans exists as a commensal organism in heal...
متن کاملOverexpression of Candida albicans CDR1, CDR2, or MDR1 does not produce significant changes in echinocandin susceptibility.
The micafungin and caspofungin susceptibilities of Candida albicans laboratory and clinical isolates and of Saccharomyces cerevisiae strains stably hyperexpressing fungal ATP-binding cassette (ABC) or major facilitator superfamily (MFS) transporters involved in azole resistance were determined using three separate methods. Yeast strains hyperexpressing individual alleles of ABC transporters or ...
متن کاملA mutation in Tac1p, a transcription factor regulating CDR1 and CDR2, is coupled with loss of heterozygosity at chromosome 5 to mediate antifungal resistance in Candida albicans.
TAC1, a Candida albicans transcription factor situated near the mating-type locus on chromosome 5, is necessary for the upregulation of the ABC-transporter genes CDR1 and CDR2, which mediate azole resistance. We showed previously the existence of both wild-type and hyperactive TAC1 alleles. Wild-type alleles mediate upregulation of CDR1 and CDR2 upon exposure to inducers such as fluphenazine, w...
متن کاملConstitutive activation of the PDR16 promoter in a Candida albicans azole-resistant clinical isolate overexpressing CDR1 and CDR2.
Candida albicans azole-resistant clinical isolates overexpressing the CDR1 and CDR2 genes (multidrug transporters) also overexpress the PDR16 gene (phosphatidylinositol transfer protein). We show here that the PDR16 promoter displays higher transcriptional activity following integration in an azole-resistant isolate than in the matched azole-susceptible one. Thus, the upregulation of PDR16 in t...
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ژورنال
عنوان ژورنال: Molecular Microbiology
سال: 2006
ISSN: 0950-382X,1365-2958
DOI: 10.1111/j.1365-2958.2006.05357.x